Using immunocytochemistry, strong expression of HER-3 was detected in five out of 12 cell lines (ICC score ≥ 2+; Table 1), whereas high (3+) or borderline (2+) expression of HER-2 was present in 50% of our model system (ICC score ≥ 2+; Table 1). Here, ERBB2 is linked to intrahepatic cholangiocarcinoma.