Besides the p.G91del mutation we reported here, together with 8 other reports [3–10], the other main group of CRYBA1 mutations have been identified in congenital cataracts: the mutations in the first two bases at the donor splice site of intron 3 (IVS3 + 1 G > A, IVS3 + 1 G > T, IVS3 + 1 G > C and IVS3 + 2 T > G) [8, 19–25]. This evidence concerns the gene CRYBA1 and Developmental cataract.