Similarly, an increased proportion of missense/in-frame mutations in individuals with NF1-related PVS [30], most of whom clinically fit with NFNS or Watson syndrome (WTSN #193520), an NF1-related trait with PVS, CaLS, and intelligence at the lower end of the normal change [31,32], was reported. Here, NF1 is linked to neurofibromatosis-Noonan syndrome.