Individuals with NF1 WGD also showed higher prevalence of CHD (3/14, 21.4%) compared to patients with intragenic mutations (59/479, 12.3%), but the difference was non-significant (odds ratio = 1.9414, 95% CI: 0.5263–7.1622, p = 0.3192), likely because of the small number of patients with these NF1 lesions. This evidence concerns the gene NF1 and coronary artery disorder.