Another in vivo study found that tumor-secreted exosomal miR-222 can stimulate AKT by constraining protein phosphatase 2 regulatory subunit Balpha (PPP2R2A) expression, and thus inducing p27 phosphorylation and cytoplasmic p27 expression to promote invasion, metastasis and survival [50]. Here, PPP2R2A is linked to neoplasm.