Accordingly, in the current investigation, the main objectives were two-fold: (1) to assess the immune tumor microenvironment (T cells) and (2) to quantify levels of oxidative stress, antioxidant enzymes, apoptosis, autophagy, signaling, and cell proliferation rates in the subcutaneous lung adenocarcinoma tumors of BALB/c mice treated with a combination of immunomodulators (anti-PD1, anti-CTLA-4, anti-CD137, and anti-CD19 monoclonal antibodies). Here, CTLA4 is linked to lung adenocarcinoma.