BHLHE41 (basic helix-loop-helix family member e41) is also known as DEC2 (differentiated embryonic chondrocyte gene 2)/SHARP1 (split and hairy-related protein 1), encodes a basic helix-loop-helix transcription factor, and is associated with the regulation of apoptosis and cell proliferation in various cancers. Here, BHLHE41 is linked to cancer.