When pterostilbene was tested in combination with histone deacetylase (HDAC) inhibitor SAHA (suberoylanilide hydroxamic acid, vorinostat), tumor tissues from prostate-specific Pten-null mice showed a reduction of MTA1-associated proangiogenic factors HIF-1α, VEGF, and IL-1β leading to decreased angiogenesis and more potent antitumor effects [32]. This evidence concerns the gene MTA1 and neoplasm.