IKZF1 and T-cell leukemia: Interestingly, IMiDs-driven downregulation of IKZF1/IKZF3 is rather non-toxic to T-cells or T-cell leukemias but results in increased expression of interleukin 2 (IL-2) and decreased expression of tumor necrosis factor alpha (TNF-α) in monocytes [16,17].