The arithmetic product of urinary IGFBP7 and urinary TIMP-2 ([IGFBP7•TIMP-2]) was identified as an AKI biomarker in a clinical study in which it outperformed ~338 other candidate biomarkers at predicting AKI based on standard clinical criteria (Table 1) [123]. The gene discussed is IGFBP7; the disease is acute kidney injury.