IGFBP7 and acute kidney injury: Recent evidence indicates that increases in urinary [IGFBP7•TIMP-2] following diverse forms AKI is contributed to by a multitude of factors, which include decreases in glomerular permeability, proximal tubular cell leakage, and impaired reabsorption of IGFBP7 and TIMP-2 in the proximal tubule [126].