Encephalitogenic T cells from MOG-induced experimental autoimmune encephalomyelitis (EAE) mice showed significantly lower levels of TSPAN32, which can be explained by a higher activity of T lymphocytes; the increased levels of CD9, CD53, CD82 and CD151 are concordant with the in vitro data, suggesting their role in the activation of the immune response. This evidence concerns the gene CD151 and experimental autoimmune encephalomyelitis.