In the same cellular model, ICA-27243 [28], a benzamide derivative showing antiepileptic activity in a broad range of rodent seizure models and provided of a certain degree of selectivity for Kv7.2/Kv7.3 channels [37], was also investigated; notably, while RTG activates Kv7.2/Kv7.3 channels by binding to the S5-S6 pore domain, ICA-27243 binds to a pocket located in the VSD [45]. The gene discussed is KCNQ2; the disease is Seizure.