An oversupply or overactivity of transcription factors via nuclear proteins is responsible for unrestrained growth and metastatic behavior of all human cancers.26 Ubiquitination not only regulates the protein substrate levels, but is also responsible for the localization and activity of key protein kinases in many signaling pathways, such as STATs, NF‐κB and PI3K/Akt.71 To lineate the activity and function of a subset of proteins, including tumor suppressor and tumor promoter proteins, is critical for our understanding of tumor development, progression and sensitivity to drug treatment. The gene discussed is NFKB1; the disease is cancer.