The plasmid EGFP‐PCNP, transfected into COS‐7 cells, was exclusively localized to the nucleus, somewhat homogeneously outside the nucleolus, avoiding nucleoli when observed under a fluorescence microscope for sub cellular localization.1 It may induce apoptotic activity by directly acting on the DNA/ nucleus of the cancer cell; if it is true then the mechanism of caspase 8 released by over expressed PCNP in neuroblastoma is a question. Here, CASP8 is linked to neuroblastoma.