CASP8 and neoplasm: Similar is the case when in the neuroblastoma anticancer study, phosphorylation of caspase 8 was observed in over expressed PCNP in tumor cells by western blot which is the executioner of the extrinsic apoptosis pathway mediated by cell membrane death receptors.51 Caspase 8 from extrinsic pathway and Caspase 9 from intrinsic merge in a single downstream pathway via Caspase 3.