MTOR and lung adenocarcinoma: On the other hand, PCNP mediates the proliferation, migration, and invasion of human lung adenocarcinoma cells via the pSTAT3/5 and PI3K/Akt/mTOR signaling pathways.10 Mitogen‐activated protein kinases and downstream regulators like PI3K/Akt/mTOR are stimulated by growth factors and cytokines.