While extra‐cardiac biopsy in clinically suspected amyloidosis can yield a diagnosis in 50% to 80% of patients with AL amyloidosis,66 this falls to 35% in patients with wild‐type ATTR‐CM.67 Furthermore, because of the potential for false negative results for ATTR amyloidosis with a non‐invasive approach, a histological diagnosis from EMB should be sought in any patient with suspected cardiac amyloidosis where non‐invasive diagnostic criteria are not met.2 This evidence concerns the gene TTR and cardiac amyloidosis.