Importantly, increasing data have indicated that STAT3 activation is related to tumor metastasis and that STAT3 promotes lung cancer metastasis through EMT.32, 33 To investigate the precise molecular mechanism of regulation by KLF3 in lung cancer metastasis, we examined the potential abnormal signaling pathway involved in lung cancer that is mediated by KLF3 using bioinformatics analysis. The gene discussed is STAT3; the disease is lung cancer.