In human metastatic sarcomas, dysregulated expression of KLF3 has been observed, and the knockdown of KLF3 has been shown to promote cancer cell metastasis.16 RNA sequencing analysis has demonstrated that KLF3 may play a protective role in colorectal cancer.17 However, the precise mechanism of the regulation of cancer metastasis mediated by KLF3 remains incompletely explained, and the role of KLF3 in lung cancer remains unclear. The gene discussed is KLF3; the disease is cancer.