STAT3 and malignant colon neoplasm: For example, the overexpression of IL‐22RA1 promotes stemness and tumorigenicity in pancreatic cancer by regulating the STAT3 signaling pathway.21 In addition, it has recently been shown that the activation of the STAT3 signaling pathway promotes colon cancer metastasis by regulating epithelial‐mesenchymal transition (EMT).22, 23 The STAT3 signaling pathway seems to be necessary for cancer metastasis.