KLF4 and colonic neoplasm: Increasing evidence has indicated that different KLF factors are involved in metastasis.27 For example, overexpressed KLF4 inhibits pancreatic cancer metastasis by regulating caveolin‐1 expression.28 Notably, Yan et al.29 also clearly showed that KLF8 promotes colon cancer tumorigenesis, invasion, and metastasis by transcriptional activation of FHL2.