Chemotherapeutic drugs can induce apoptosis, leading to a decrease in VEGF secretion and a decrease in VEGFR‐2 expression, thereby inhibiting angiogenesis and further tumor growth, and (ii) EGFR and VEGFR2 may synergistically inhibit tumors by inhibiting the MAPK‐ERK and PI3K‐AKT‐mTOR pathways (Fig 7). This evidence concerns the gene KDR and neoplasm.