In addition, the sensitivity of normal mice to VEGF inhibitors was much lower than that of tumor‐bearing mice, and the blood vessels were able to regenerate after withdrawal of the drug.29 Our study indicated that no obvious pathological damage was found in the vital organs of the heart, brain, liver or kidney of nude mice after treatment with apatinib combined with chemotherapy or EGFR‐TKI, and the MVD of the heart and brain did not change significantly; however, the MVD of the liver and kidney was significantly decreased. Here, EGFR is linked to neoplasm.