Its possible mechanism is to reduce the expression of VEGF through the mechanism of both hypoxia inducible factor (HIF)‐1‐independence and HIF‐1 dependence.20 Anti‐angiogenic therapy not only reduces the formation of new blood vessels, but also induces tumor vascular normalisation,21 thereby increasing the local drug concentration of the tumor and enhancing the anti‐tumor activity. This evidence concerns the gene VEGFA and neoplasm.