AKT1 and neoplasm: Chemotherapeutic drugs can induce apoptosis, leading to a decrease in VEGF secretion and a decrease in VEGFR‐2 expression, thereby inhibiting angiogenesis and further tumor growth, and (ii) EGFR and VEGFR2 may synergistically inhibit tumors by inhibiting the MAPK‐ERK and PI3K‐AKT‐mTOR pathways (Fig 7).