To determine the functional role of NDRG2 in neuroblastoma, overexpression of NDRG2 was induced in the neuroblastoma cell lines SK-N-SH and SH-SY5Y, which resulted in an increased expression of the tumor suppressor gene protocadherin 17 and differentiation-related genes such as Rsu1 and Smurf1, and the decreased expression of proliferation-related genes such as CYR61. Here, NDRG2 is linked to neuroblastoma.