TGFB1 and chronic kidney disease: We found that the most obvious expression changes were among genes in the Notch pathway and genes of cell cycle repressors, while the expression of most genes in the TGFβ and Wnt pathways was not significantly altered by cKD of Foxg1. Many previous studies have suggested that Notch is a very important pathway involved in HC regeneration [5, 8, 12–14, 19, 24, 74, 84, 88], and down-regulation of the Notch signaling pathway in the Foxg1 cKD SCs might be one of the important mechanisms leading to the phenotype of extra HCs.