To determine whether Foxg1 cKD in Lgr5+ progenitors also leads to extra HCs, we crossed Lgr5-EGFP-CreERT2 mice with Foxg1-floxp mice to generate Lgr5-EGFPCreER/+ Foxg1loxp/loxp double-positive mice. The gene discussed is LGR5; the disease is chronic kidney disease.