CXCL10 and CXCL9 are secreted by human IFN-γ+TNF-α-stimulated hepatic sinusoidal endothelial cells in vitro, suggesting that in CHC the production of IFN-γ in the liver causes the raised CXCL10 and CXCL9 expression and recruits CXCR3-expressing T cells in the hepatic lobule [56]. This evidence concerns the gene CXCR3 and cryohydrocytosis.