In CHC, the HCV and intrahepatic production of IFN-γ drive a raised CXCL10 and CXCL9 expression by sinusoidal endothelium, and by hepatocytes, and thereby promote the continuing recruitment of CXCR3-expressing T cells into the hepatic lobule. The gene discussed is CXCL9; the disease is cryohydrocytosis.