We have previously demonstrated that vasodilation of epineurial arterioles, blood vessels that provide circulation to the sciatic nerve, to acetylcholine is decreased prior to slowing of nerve conduction velocity in diabetic rats, and after 8 weeks of chronic hyperglycemia vasodilation to calcitonin, gene-related peptide is also decreased [14, 15]. The gene discussed is CALCA; the disease is Hyperglycemia.