EGFR and head and neck squamous cell carcinoma: Among them, only cetuximab has been confirmed in the treatment of metastatic or recurrent HNSCC and was approved in combination with radiation by the US FDA for the treatment of unresectable HNSCC.EGFR inhibitors-tyrosine kinase inhibitors (TKIs), which consist of gefitinib, erlotinib and lapatinib, are also being investigated in the treatment of advanced/recurrent HNSCC, but there is no clear consensus on their true efficacy[45].