Reviewing the recent literature, we find that the overexpression of The epidermal growth factor receptor (EGFR) has been noted in up to 90% of HNSCC [43]and the EGFR mutation was associated with the grading and staging of HNSCC[44].EGFR inhibitors -monoclonal antibodies (mAbs) include cetuximab, panitumumab, zalutumumab and nimotuzumab. Here, EGFR is linked to head and neck squamous cell carcinoma.