AGTR1 and hypertensive disorder: Three doses of subcutaneous immunization with 100 μg of AT1R-KLH in combination with FCA at first administration and FIA at following administrations to SHRs at 4, 6, and 8 weeks of age attenuated the elevation of blood pressure (systolic blood pressure of vaccinated rats −44 mmHg vs. control rats); this attenuation of hypertension was equivalent to that provided by continuous administration of candesartan cilexetil (0.1 mg·kg−1·day−1) and was sustained for 25 weeks after the final immunization [54].