It was not until it was revealed that renal ischemia induced an increase in blood pressure in dogs [9] and numerous investigators tried to elucidate the pathogenesis of hypertension using renal ischemia models that renin received extensive attention, which resulted angiotensin (Ang) being identified as a substance that causes renal hypertension [10, 11]. The gene discussed is REN; the disease is renal hypertension.