Three doses of subcutaneous immunization with Ang II-KLH vaccine together with Freund's adjuvants induced anti-Ang II serum IgG antibody that penetrated into ischemic lesions across a broken blood-brain barrier, resulting in inhibition of oxidative stress and reduction in infarction size after induction of cerebral infarction in Wistar rats [61]. Here, AGT is linked to cerebral infarction.