PRF1 and neoplasm: The tumour‐immune cell response is thought to commence with the recognition of TAAs or neoantigens that are either released into the TME or recognised on the surface of tumor cells themselves (Figure 1).7, 8 Inflammatory signals induced by growing tumors may recruit infiltrative innate cells, such as NK cells, to the tumor site, which induce tumor cell apoptosis through interferon gamma (IFNγ) and perforin release.