TARDBP and Alzheimer disease: Although no difference was detected in the comparison of wt and TDP-43G298S mice at baseline (in agreement with the FA values), the whole-brain voxelwise comparison of AD, MD and RD in wt vs TDP-43 mice at follow-up revealed a significant increase of RD in the motor cortex, whereas clusters on decreased AD were detected in correspondence of the retrosplenial cortex (Fig. 4).