The results showed that the urinary mTOR mRNA level effectively distinguished moderate-to-severe fibrosis from none-mild fibrosis, with the largest AUC of 0.739 (95% CI: 0.654-0.824; P < 0.001), higher than that of eGFR (AUC of 0.492; 95% CI: 0.395-0.588; P = 0.868), Scr (AUC of 0.513; 95% CI: 0.414-0.612; P = 0.794), BUN (AUC of 0.499; 95% CI: 0.400-0.598; P = 0.981), 24 h proteinuria (AUC of 0.510; 95% CI: 0.401-0.618; P = 0.850), and Cys-c (AUC of 0.495; 95% CI: 0.388-0.603; P = 0.055). The gene discussed is MTOR; the disease is fibrosis.