Thus, deficiency protocadherins could lead placental lesions, which were defined as maternal vascular lesions, were more common in pregnancies that were complicated by hypertensive disorders [31], although PIH is primarily an impairment of the maternal circulatory system that is believed to be the result of early developmental events that lead to inadequate vascular remodeling and/or structural abnormalities of maternal arteries [32]. Here, PCDH11X is linked to hypertensive disorder.