An early study reported that AML homing occurs around vessels of a specialized E-selectin and CXCL12 positive endothelium [7], two subsequent studies reported that leukemic engraftment occurs in areas enriched with osteoblasts [8, 9], and another has shown that LSCs are themselves able to generate walled-off abnormal niches [10]. Here, SELE is linked to acute myeloid leukemia.