In PaCa Tspan8 is associated with several CIC markers like α6β1, CD104, EpCAM, CXCR4, and CD44v6 [6], a reduction of Tspan8 expression being frequently associated with reduced expression of the associated molecules. This evidence concerns the gene CXCR4 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.