NLRP3 and Hyperglycemia: However, if hyperglycemia was not rectified, the accumulation of damaged mitochondria, other ubiquitin, and injured organelles exceeds the autophagy-scavenging capacity, thus releasing ROS and mitochondrial DNA into the cytoplasm, causing continuous activation of NLRP3 inflammasome, which indicates that excessive intracellular stress resulting from hyperglycemia may lead to autophagy as a consequence of cellular damage.