Up-regulation of HMGB1 isassociated with the hallmarks of cancer and clinically it hascrucial role in the autoimmune diseases, apart from cancer[6-8].Phenolics are natural antioxidant obtained from plants one ofthem is chlorogenic acid (CGA), naturally present in coffee,apple, mulberry, Achyranthes aspera etc[9]. Here, HMGB1 is linked to cancer.