Overall, our finding based on results of HMGB1 protein structuremodel is very trustworthy, first ever report in mice and could beutilized for the docking as well as prediction of CGA, CGAconformerslike natural biomolecule drugs that should bound tothe prominent active target site of cancer causing inflammatorycytokine HMGB1 to prevent and cure several types of cancer. This evidence concerns the gene HMGB1 and cancer.