Since our observations indicate that knockdown of RPSAP52 results in a reduction in HMGA2 expression23, we decided to look further into the molecular mechanism of RPSAP52-mediated regulation of the locus. A panel of breast cancer cell lines was used to confirm the presence of RPSAP52 transcript by semi-quantitative PCR (Fig. 1d). The gene discussed is RPSAP52; the disease is breast cancer.