Of note, MGST1 is involved in the glutathione metabolism pathway and a marker of Ewing’s sarcoma prognosis40, high levels of NPY (a direct target of the EWS-FLI1 fusion) promotes the metastasis of Ewing’s sarcoma models in vivo41, CRABP1 and CPT1C favor tumor malignancy42,43, and CD109 and PTPRZ1 are highly expressed in several cancer types (including sarcoma cell lines44) and promote stem cell-like properties45. This evidence concerns the gene FLI1 and sarcoma.