HMGA2 and cancer: However, while other studies have reported lncRNAs that interact with IGF2BP2 and compete for its binding to target mRNAs (e.g., LncMyoD promotes muscle differentiation by outcompeting c-Myc and N-Ras mRNAs for IGF2BP2 binding48), in the cancer setting that we are studying reexpression of RPSAP52 facilitates IGF2BP2 binding to a subset of mRNA targets, prominently HMGA2 and LIN28B mRNAs.