CDK4 and colorectal carcinoma: On cell cycle regulation, CD36 overexpression resulted in cell cycle arrest while knockdown of CD36 promoted cell cycle progression in CRC cells, and western blot analysis showed different CD36 status had opposite regulations on cell-cycle governors, like Cyclin D1, CDK4, CDK6, p21 and p18 (Fig. 2c and Supplementary Fig. 2d).