MYC and colorectal carcinoma: As expected, knockdown of CD36 rendered CRC cells much more sensitive to both β-catenin inhibitor XAV-93938 and c-myc inhibitor 10058-F439, as indicated by more severe repression of the protein expression of downstream glycolytic genes and more cell death in RKO and CACO2 cells with shCD36 than were in control cells (Fig. 3d, e).