In pancreatic adenocarcinoma, although it is reported that CD36 on immune cells is indispensable for pancreatic tumor microvesicles to extravasate and form premetastatic foci16, CD36 may act as a tumor-suppressive gene in pancreatic cancer (PC) as its expression was downregulated in tumors and its deficiency in PC cells predicted large tumor burden and poor prognosis15, which further suggest the unique cell type-specific, context-specific and function-specific roles of CD36 even in the same cancer type. The gene discussed is CD36; the disease is pachyonychia congenita.