Mechanically, the tumor-suppressive effects of CD36 were mediated through promoting the proteasome-dependent ubiquitination of GPC4, and the degraded GPC4 failed to activate β-catenin/c-myc signaling cascades and downstream glycolytic target genes GLUT1, HK2, PKM2 and LDHA (Fig. 7f). This evidence concerns the gene HK2 and neoplasm.