Female HF-fed Ace2Adipo mice exhibited an increased maximal blood pressure response to AngII (Fig. 4a; p < 0.05) that was extended in duration compared to HF-fed Ace2fl/fl females, as evidenced by an increased AUC (blood pressure response above baseline through 60 min; Fig. 4c; p < 0.05). The gene discussed is AGT; the disease is hydrops fetalis.