After the initial approval of ipilimumab (a monoclonal antibody blocking CTLA-4) for the treatment of metastatic melanoma, five more antibodies that target PD-1/PD-L1 pathways, including nivolumab and pembrolizumab (against PD-1) and atezolizumab, avelumab, and durvalumab (against PD-L1), have been licensed and introduced into the therapeutic algorithms for various malignancies in first and later lines of treatment, as well as in the neoadjuvant and adjuvant settings [1]. The gene discussed is CD274; the disease is metastatic melanoma.