TNF and cancer: First, the risk of MTB in these types of cancer is significantly lower compared to other immunocompromised groups, such as patients with HIV (RR:50–110) [47, 48], contact with individuals with active MTB (RR:10.4) [49], patients with chronic renal failure (RR:7.8) [5] and patients being treated with TNF-a inhibitors (RR:1.8–29.3) [50].