KIT and mast cell leukemia: GIST-T1 cells (KIT⊿560–578) grow in a manner dependent on KIT signaling on the Golgi, whereas HMC-1.2 (mast cell leukemia, KITV560G/D816V) requires pAKT on EL and pSTAT5 on the ER [24–27] (Additional file 1: Figure S6A & Table 1).