PROS1 and rheumatic disorder: Aortic thrombi can be caused by blood disorders (e.g., protein S or protein C deficiency and anti-phospholipid antibody syndrome), tumors, aortitis, collagen disease, aortic structural abnormalities (e.g., aortic aneurysms), intra-aortic atheroma, hormone therapy, steroid use, and atrial fibrillation [9].