CD4 and Hepatic fibrosis: Thus, in some studies, Rapamycin was used to inhibit the differentiation of Th17 cells and promote the proliferation and differentiation of Treg cells in kidney transplant recipients [15], murine CD4+ T cell transfer model of colitis and an experimental autoimmune encephalomyelitis (EAE) model [16] and CCl4-induced liver fibrosis [17].