VEGFA and neoplasm: On the contrary, M2 macrophages own potent pro-tumor activity producing a high amount of anti-inflammatory cytokines, including CCL18, IL-10, VEGF, and MMPs, thus determining the recruitment and activation of immunosuppressive cells, such as Treg and MDSCs, as well as the inhibition of T cell responses, thus promoting tumor invasion and metastasis (Figure 1A).