Factors that are produced by the stromal components, such as VEGFA, and molecules that are released by tumor cells and immune cell populations, including inflammatory cytokines and chemokines (e.g., TGF-β and TNF-α), represent the main players in conditioning PMNs in distant organs that are favorable to the survival and outgrowth of the recruited cancer cells [26]. This evidence concerns the gene VEGFA and neoplasm.