In fact, it contains several pro-angiogenic growth factors, such as vascular endothelial growth factor A (VEGFA), fibroblast growth factors (FGFs), platelet-derived growth factor-beta (PDGF-β), and transforming growth factor-beta (TGF-β), which are proteolytically activated by plasmin, MMPs, or other proteases that are released by stromal and/or cancer cells [7,8]. This evidence concerns the gene TGFB1 and cancer.