Consistent with the high expression of PD-L1, clinical studies that were carried on patients with melanoma, NSCLC, urothelial cancer, renal carcinoma, head and neck squamous cell carcinoma and gastric cancer treated with these check-point blockade antibodies showed an overall response rate (ORR) that ranged from 30% to 53% [3,68]. Here, CD274 is linked to melanoma.