ALDOB and colonic neoplasm: Conversely, an increase of the ALDOB enzyme is frequently found in other tumor species, such as in colon cancer [36], rectal cancer [37], and colorectal adenocarcinoma [38], which was also associated with tumor progression and poor prognosis, and a decrease of the ALDOB transcript and ALDOB protein is found in gastric cancer [39] and in chRCC [28], also associated with poor prognosis [39].