T-DM1 has a tolerable toxicity profile [38] and merits potential investigation in SCLC clinical trials, as preclinical assessment of this compound in vivo in trastuzumab-resistant HER2-positive SCLC xenografts demonstrated that-DM1 was able to induce apoptosis in SBC-3/SN-38 xenografts to a greater extent than trastuzumab monotherapy [67]. Here, ERBB2 is linked to small cell lung carcinoma.