VKORC1 and hemorrhage: Inhibition of the VKORC1 by vitamin K antagonists such as warfarin leads to inhibition of recycling, which results in a hemorrhage due to a deficiency of activated clotting factors II, VII, IX, and X. This is indicative of the central role played by VKORC1 in the low vitamin K requirement, and any change in this activity may lead to an increased or decreased vitamin K requirement [14].