Moreover, CSF DJ-1 has also been studied as a useful parameter for a differential diagnosis between PD and other neurodegenerative diseases; however, no differences were found in DJ-1 CSF levels among PSP, dementia with LBs, or multiple system atrophy (MSA) individuals [65], while the combined detection of DJ-1 and total tau levels in CSF significantly improved the discrimination between MSA and PD. This evidence concerns the gene PARK7 and neurodegenerative disease.