In this sense, we and others have contributed to identify various cancer risk biomarkers that exhibited higher predictability beyond dysplasia grading, such as Cortactin (CTTN), the focal adhesion kinase (FAK) and Podoplanin (PDPN) that were strong independent predictors of oral cancer risk but not histopathological diagnosis [24,25]. This evidence concerns the gene PDPN and lip and oral cavity carcinoma.