VTN and plasma cell myeloma: Examples of bioactive ECM-protein fragments are: Laminin-511 (a combination of α5, β1 and γ1 laminin chains) produced recombinantly in human embryonic kidney cells [5]; the N-terminal somatomedin B domain of vitronectin expressed in Escherichia coli [6]; and the Fn7-Fn14 fragment from fibronectin expressed in mouse myeloma cells [7].