Fabry disease, an X-linked lysosomal storage disorder, is caused by the deficiency or absence of alpha-galactosidase A (α-Gal-A), which leads to an accumulation of globotriaosylceramide/ceramide trihexoside (Gb3) with a terminal a-D-galactosyl residue, particularly globotriaosylceramide (GL-3, Gb3, CTH) and globotriaosylsphingosine (Lyso-GL-3, lyso-Gb3) [134,135]. This evidence concerns the gene GLA and Fabry disease.