The cytotoxicity of combined AZ628 and BP-1-102 is enhanced in KRAS(G12D) H838 cells compared with KRAS(WT) H838 cells, and the CI values were < 0.7 in all groups with different concentrations combination, suggesting a strongly synergistic interaction between AZ628 and BP-1-102 in KRAS mutant lung cancer cells (Figure 1). This evidence concerns the gene KRAS and lung cancer.