FMO5 and hypertensive disorder: For example, O2− generated from NAD(P)H oxidase reacts with NO, forming peroxynitrite (ONOO−), which consequently induces changes in the NOS enzyme subunits resulting in further O2− formation and the declination of NO bioavailability, which impairs endothelium‐dependent relaxation in a model of salt‐induced hypertensive rats.111 ROS synthesized by NAD(P)H oxidase is required for iNOS expression in microvascular EC.112