Given that Snail transcription factors are known to regulate the expression of various mesenchymal markers associated with tumor invasion, metastasis, and cell motility [46–48], we determined, first, whether there was an analogous relation between the induction of Snail1/2 and profibrotic targets connected with TGF-β mediated EMT (Fig 4B); and most importantly, second, if B7-1 was required for the response (Fig 4C–4E). The gene discussed is TGFB1; the disease is neoplasm.