TGFB1 and familial pancreatic carcinoma: While it is currently unknown if B7-1 has any role in this process, as TGF-β ligands are commonly overexpressed in pancreatic cancer and can promote epithelial to mesenchymal transition (EMT) and invasion [69, 70], we next investigated whether B7-1 was required for the induction of TGF-β target/regulatory genes and biological phenotypes associated with pancreatic cell EMT.