The mean percentage of positively stained cells for S1PR-3 was significantly increased in endothelial cells (64.15 ± 1.86%), alveolar epithelial cells (60.03 ± 2.72%) and alveolar macrophages (48.69 ± 4.89%) in the lung tissues of the ALI/ARDS group compared with that in the non-ALI/ARDS group (endothelial cells: 38.61 ± 2.09%; alveolar epithelial cells: 31.01 ± 1.45%, alveolar macrophages: 33.95 ± 3.57%) and the control group (endothelial cells: 35.674 ± 2.49%; alveolar epithelial cells: 27.07 ± 2.47%, alveolar macrophages: 27.05 ± 3.75%) (all p < 0.001). The gene discussed is S1PR3; the disease is acute respiratory distress syndrome.