The mean total score of SphK-1 and S1PR-3 expression was significantly upregulated in endothelial cells, alveolar epithelial cells, and alveolar macrophages in the lung tissues of the ALI/ARDS group compared with that in the non-ALI/ARDS and control groups (all p < 0.001). Here, S1PR3 is linked to acute respiratory distress syndrome.