SNHG16 is overexpressed in various types of human cancers.19, 20, 21, 36 Moreover, increased expression of SNHG16 independently predicts a poor prognosis of patients with NSCLC22 and bladder cancer.20 In addition, serum SNHG16 expression is suggested as a potential early diagnostic biomarker for lung cancer.37 Here we found that DLBCL tissues from patients with advanced tumour stages showed prominent higher levels of SNHG16 compared with those from patients with early tumour stages. This evidence concerns the gene SNHG16 and cancer.