NKD1 and cancer: Moreover, most of the potential NKD genes were NK cell–activating receptors, which depend on ITAM signaling.17 Thus, we hypothesized that other ITAM-signaling genes (ie, non-NK-specific ITAM genes, which had been excluded from analysis owing to their higher expression in cancer or other immune cells) in NK cells could have more inherited defective genes in TIME-poor tumors than in TIME-rich tumors and would also be associated with survival and the abundance of TILs.