Indeed, the combined genes (ie, significantly defective non-NK-specific ITAM-genes and the potential NKD genes) significantly improved the association of the number of defective genes among the combined genes with 10 of 12 cancer types (ie, lower P values and correlation coefficients; patients with HNSC: R = −0.25; 95% CI, −0.65-2.17; P = .02) (eTable 7, eFigure 12, eFigure 13, and eAppendix 1 in the Supplement). This evidence concerns the gene NKD1 and cancer.