NKD1 and cancer: Surveillance of cancerous cells and the regulation of the active immune system by NK cells have been investigated.26,27 A 2017 comprehensive review summarized a number of studies about NK defects and cancer development and relapse.28 Our findings suggest that NKD genes were associated with the recruitment of immune cells into TIMEs, and inherited defective genes in NK, NK T cells, and/or γδ T cells probably impaired communication between NK cells and other immune cells to block the recruitment of TILs.